Pravadoline is a nonacidic, aminoalkylindole analgesic agent that inhibits cyclooxygenase. pravadoline synthesis, for sale usa, erowid, r win55212
Like NSAIDs, pravadoline inhibits prostaglandin synthesis (IC50 = 5 μM in mouse brain microsomes) and displays antinociceptive activity (ED50 = 26 mg/kg in an acetylcholine-
In contrast to NSAIDs, pravadoline inhibits neuronally stimulated contractions in mouse vas deferens preparations (IC50 = 0.45 μM), an effect similar to that which is produced by opioid analgesics, yet is not attenuated by the opioid receptor antagonist, naloxone.
Pravadoline does not produce gastrointestinal irritation following acute or chronic administration to rodents. pravadoline synthesis, for sale usa, erowid, r win55212
Chemical and physical data
Molar mass 378.46 g/mo
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